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Generic Name:epoetin alfa

Medically reviewed by Drugs.com. Last updated on Oct 14, 2020.

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Note: This document contains side effect information about epoetin alfa. Some of the dosage forms listed on this page may not apply to the brand name Procrit.

In Summary

Common side effects of Procrit include: upper respiratory tract infection, arthralgia, decreased serum iron, diarrhea, edema, fever, low serum ferritin, paresthesia, respiratory congestion, skin rash, tachycardia, cough, dyspnea, headache, nausea, signs and symptoms of injection site, and vomiting. Other side effects include: chest pain. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to epoetin alfa: injection solution

Warning

Injection route (Solution)

ESAs increase the risk of death, myocardial infarction, stroke, venous thromboembolism, thrombosis of vascular access, and tumor progression or recurrence.Chronic Kidney Disease:In controlled trials, patients experienced greater risks for death, serious adverse cardiovascular reactions, and stroke when administered erythropoiesis-stimulating agents (ESAs) to target a hemoglobin level greater than 11 g/dL.No trial has identified a hemoglobin target level, ESA dose, or dosing strategy that does not increase these risks.Use the lowest epoetin alfa-epbx dose sufficient to reduce the need for red blood cell (RBC) transfusions.Cancer:ESAs shortened overall survival and/or increased the risk of tumor progression or recurrence in clinical studies of patients with breast, non-small cell lung, head and neck, lymphoid, and cervical cancers.To decrease these risks, as well as the risk of serious cardiovascular and thromboembolic reactions, use the lowest dose needed to avoid RBC transfusions.Use ESAs only for anemia from myelosuppressive chemotherapy.ESAs are not indicated for patients receiving myelosuppressive chemotherapy when the anticipated outcome is cure.Discontinue following the completion of a chemotherapy course.Perisurgery:Due to increased risk of deep venous thrombosis (DVT), DVT prophylaxis is recommended.

Side effects requiring immediate medical attention

Along with its needed effects, epoetin alfa (the active ingredient contained in Procrit) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking epoetin alfa:

More common

• Black, tarry stools
• blurred vision
• body aches or pain
• bone pain
• chest pain
• chills
• cough
• dry mouth
• ear congestion
• fever
• flushed, dry skin
• fruit-like breath odor
• increased hunger
• increased thirst
• increased urination
• itching, skin rash
• loss of voice
• nervousness
• pain, redness, or swelling in the arm or leg
• painful or difficult urination
• pounding in the ears
• runny or stuffy nose
• slow or fast heartbeat
• sneezing
• sores, ulcers, or white spots on the lips or in the mouth
• stomach pain
• swollen glands
• tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins over the affected area
• trouble breathing
• unusual bleeding or bruising
• unusual tiredness or weakness

Less common

• decreased urine
• difficulty swallowing
• fainting
• loss of appetite
• mood changes
• muscle pain or cramps
• numbness or tingling in the hands, feet, or lips
• swelling

Incidence not known

• Blistering, peeling, or loosening of the skin
• dark urine
• fluid-filled skin blisters
• joint pain
• light-colored stools
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• red skin lesions, often with a purple center
• red, irritated eyes
• sensitivity to the sun
• skin thinness
• tightness in the chest
• yellow eyes or skin

Side effects not requiring immediate medical attention

Some side effects of epoetin alfa may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Decreased weight
• difficulty in moving
• injection site irritation or pain
• muscle spasm or stiffness
• swelling or inflammation of the mouth
• swollen joints
• trouble sleeping

Less common

• Discouragement
• feeling sad or empty
• irritability
• loss of interest or pleasure
• trouble concentrating

For Healthcare Professionals

Applies to epoetin alfa: injectable solution

General

The most common adverse reaction was dose-dependent increase in blood pressure or aggravation of existing hypertension.^[Ref]

Gastrointestinal

Very common (10% or more): Nausea (up to 56%), diarrhea (up to 30%), vomiting (up to 28%), stomatitis (10%)

Common (1% to 10%): Dysphagia

Frequency not reported: Vomiting^[Ref]

Other

Very common (10% or more): Pyrexia (up to 42%)

Common (1% to 10%): Chills, influenza-like illness, peripheral edema, artificial kidney clotting during dialysis, edema^[Ref]

Nervous system

Very common (10% or more): Headache (up to 34%)

Common (1% to 10%): Convulsion, dizziness

Frequency not reported: Cerebrovascular accident, transient ischemic attack^[Ref]

Cardiovascular

Very common (10% or more): Hypertension (up to 33%), embolism and thrombosis (up to 15%)

Common (1% to 10%): Deep vein thrombosis, thrombosis

Uncommon (0.1% to 1%): Myocardial infarction

Frequency not reported: Blood pressure increased, aneurysm^[Ref]

Respiratory

Very common (10% or more): Cough (up to 26%)

Common (1% to 10%): Respiratory tract congestion, upper respiratory tract infection, pulmonary embolism^[Ref]

Dermatologic

Very common (10% or more): Rash (up to 25%), pruritus (up to 21%)

Common (1% to 10%): Urticaria

Uncommon (0.1% to 1%): Erythema

Frequency not reported: Angioedema

Postmarketing reports: Severe cutaneous reactions^[Ref]

Musculoskeletal

Very common (10% or more): Arthralgia (up to 24%), pain in extremity (up to 15%), myalgia (up to 10%)

Common (1% to 10%): Bone pain, muscle spasm

Frequency not reported: Porphyria^[Ref]

Local

Very common (10% or more): Injection site reaction (up to 18%), injection site pain (up to 13%)

Common (1% to 10%): Vascular access thrombosis^[Ref]

Metabolic

Very common (10% or more): Hyperkalemia (up to 10%)

Common (1% to 10%): Weight decrease, hyperglycemia, hypokalemia^[Ref]

Psychiatric

Common (1% to 10%): Insomnia, depression^[Ref]

Hematologic

Common (1% to 10%): Leukopenia

Postmarketing reports: Erythropoietin antibody-mediated pure red cell aplasia, thrombocytopenia^[Ref]

Immunologic

Frequency not reported: Anaphylactic reaction, hypersensitivity

Postmarketing reports: Serious allergic reaction^[Ref]

References

1. Cerner Multum, Inc. 'Australian Product Information.' O 0

2. 'Product Information. Epogen (epoetin alfa).' Amgen, Thousand Oaks, CA.

3. Cerner Multum, Inc. 'UK Summary of Product Characteristics.' O 0

4. 'Product Information. Procrit (epoetin alfa).' Ortho Biotech Inc, Raritan, NJ.

Frequently asked questions

More about Procrit (epoetin alfa)

• During Pregnancy or Breastfeeding

Consumer resources

Other brands

Epogen, Retacrit

Professional resources

Related treatment guides

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Generic Name:epoetin alfa (e POE e tin AL fa)
Brand Name:Epogen, Procrit, Retacrit

Medically reviewed by Drugs.com. Last updated on May 28, 2020.

What is Procrit?

Procrit (epoetin alfa) is a man-made form of a protein that helps your body produce red blood cells. This protein may be reduced when you have kidney failure or use certain medications. When fewer red blood cells are produced, you can develop a condition called anemia.

Procrit is used to treat anemia caused by chemotherapy or chronic kidney disease, or anemia caused by taking zidovudine to treat HIV (human immunodeficiency virus).

Procrit is also used to reduce the need for red blood cell transfusions in people having certain types of surgery.

Warnings

Procrit can cause serious side effects, including heart attack or stroke. Epoetin alfa may also speed up tumor growth, or shorten remission or survival time in some people. Talk with your doctor about the risks and benefits of using Procrit.

You should not use Procrit if you have uncontrolled high blood pressure, or if you have ever had pure red cell aplasia (PRCA, a type of anemia) caused by using epoetin alfa or darbepoetin alfa.

Call your doctor at once if you have signs of a blood clot: sudden numbness or weakness, problems with vision or speech, chest pain, trouble breathing, pain or cold feeling in an arm or leg.

Before taking this medicine

You should not use Procrit if you are allergic to epoetin alfa or darbepoetin alfa, or if:

• you have untreated or uncontrolled high blood pressure;

• you have had pure red cell aplasia (PRCA, a type of anemia) after using darbepoetin alfa or epoetin alfa; or

• you use an Procrit multi-dose vial and you are pregnant or breast-feeding.

Do not use Procrit from a multi-dose vial when giving medicine to a baby. The multi-dose vial contains an ingredient that can cause serious side effects or death in very young infants or premature babies.

Epoetin alfa may speed up tumor growth, or shorten remission or survival time in some people with certain types of cancer. Talk with your doctor about the risks and benefits of using epoetin alfa.

Tell your doctor if you have ever had:

• heart disease, high blood pressure;

• a heart attack, or blood clot;

• a seizure disorder;

• phenylketonuria (PKU); or

• kidney disease (or if you are on dialysis).

It is not known whether Procrit will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.

Do not use Procrit from a multi-dose vial if you are pregnant or breast-feeding.

Epoetin alfa is made from donated human plasma and may contain viruses or other infectious agents. Donated plasma is tested and treated to reduce the risk of contamination, but there is still a small possibility it could transmit disease. Ask your doctor about any possible risk.

How should I use Procrit?

Use Procrit injection exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Procrit is injected under the skin, or as an infusion into a vein. A healthcare provider may teach you how to properly use the medication by yourself.

Read and carefully follow any Instructions for Use provided with your medicine. Do not use Procrit if you don't understand all instructions for proper use. Ask your doctor or pharmacist if you have questions.

Prepare your injection only when you are ready to give it. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine.

Do not shake a Procrit vial or you may ruin it.

Call your doctor if you feel weak, tired, or light-headed. These may be signs that your body has stopped responding to epoetin alfa.

You may need frequent medical tests to be sure this medicine is not causing harmful effects. Your injections may be delayed based on the results.

You may be given other medications to help prevent serious side effects. Keep using these medicines for as long as your doctor has prescribed.

If you need surgery, tell the surgeon ahead of time that you are using epoetin alfa. You may need to use a medicine to prevent blood clots.

Procrit is only part of a complete treatment program that may also include a special diet. Follow your doctor's instructions very closely.

Store in the refrigerator and protect from light. Do not freeze Procrit, and throw away the medication if it has become frozen.

Each single-use Procrit vial (bottle) of this medicine is for one use only. Throw it away after one use, even if there is still medicine left inside. Throw away any leftover medicine in a multi-dose vial 21 days after the first use.

Procreate To After Effects

Use a needle and syringe only once and then place them in a puncture-proof 'sharps' container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose of Procrit.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using Procrit?

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

Procrit side effects

Get emergency medical help if you have signs of an allergic reaction to Procrit (hives, sweating, rapid pulse, wheezing, trouble breathing, severe dizziness or fainting, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Epoetin alfa can cause serious side effects, including heart attack or stroke. Seek emergency medical help if you have:

• heart attack symptoms - chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;

• signs of a stroke - sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;

• signs of a blood clot - pain, swelling, warmth, redness, cold feeling, or pale appearance of an arm or leg; or

• increased blood pressure - severe headache, blurred vision, pounding in your neck or ears, anxiety, nosebleed.

Call your doctor at once if you have:

• unusual tiredness;

• a seizure (convulsions);

• high blood sugar - increased thirst, increased urination, dry mouth, fruity breath odor;

• low potassium - leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling; or

• increased blood pressure - severe headache, blurred vision, pounding in your neck or ears, anxiety, nosebleed.

Common Procrit side effects may include:

• increased blood pressure;

• joint pain, bone pain, muscle pain;

• itching or rash;

• fever, chills, cough;

• mouth pain, trouble swallowing;

• nausea, vomiting;

• headache, dizziness;

• trouble sleeping;

• depressed mood;

• weight loss; or

• pain or redness where the medicine was injected.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Procrit?

Other drugs may interact with epoetin alfa, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Frequently asked questions

Windows Equivalent To Procreate

More about Procrit (epoetin alfa)

• During Pregnancy or Breastfeeding

Consumer resources

Other brands

Epogen, Retacrit

Professional resources

Procreate To After Effects Template

Related treatment guides

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Procrit only for the indication prescribed.

Adding Fonts To Procreate

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 1996-2021 Cerner Multum, Inc. Version: 10.01.